The name scleroderma literally means “hard skin” because the disease results from a patient’s immune system attacking their organs, which in turn can stimulate overproduction of collagen (the key protein component in scar tissue), leading to the hardening and tightening of the skin and connective tissues (fibrosis). Luke Evnin: Scleroderma is a rare and often life-threatening autoimmune disease that can cause fibrosis in the skin and other vital organs. ![]() Katie Couric Media: First and foremost, what is scleroderma?ĭr. Katie spoke to Luke Evnin, Ph.D., the chairman of SRF’s Board of Directors, to learn more about Saget’s legacy. Upon his passing, people have been reflecting on the impact Saget had in both the comedy and medical worlds.
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